Bioactive marine and terrestrial polyketide and peptide secondary metabolites and perspectives of their biotechnological production
Institute of Biotechnology and Food Science, Faculty of Chemical and Food Technology STU, SK-812 37 Bratislava, Slovak Republic
a Institute of Biochemistry, Nutrition and Health, Faculty of Chemical and Food Technology STU, SK-812 37 Bratislava, Slovak Republic
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Abstract: Marine invertebrates and microorganisms are the sources of novel, bioactive secondary metabolites. Structurally, many of these compounds appear to be biosynthesized by polyketide synthase and nonribosomal peptide synthase, that have been found in terrestrial microbes and marine organisms. This review describes the scientific advances during the last 10 years in the emerging field of the molecular genetics of polyketide and nonribosomal peptide natural products isolated from marine organisms.
Keywords: marine microorganisms, marine gene cluster, polyketide synthase (PKS), nonribosomal peptide synthase (NRPS)
Full paper in Portable Document Format: acs_0062.pdf
Acta Chimica Slovaca, Vol. 3, No. 1, 2010, pp. 103—119