Acta Chimica Slovaca (ACS) publishes papers on fundamental and applied aspects of chemistry, biochemistry, chemical technology, chemical engineering and process control, biotechnology and food technology. Welcome are also topics which include chemical aspects of materials, physical chemistry and chemical physics, analytical chemistry, macromolecular chemistry and biomedical engineering.

Impact of packing density on primary drying rate

Anna Matejčíková, Pavol Rajniak *

Department of Chemical and Biochemical Engineering, Institute of Chemical and Environmental Engineering, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Radlinského 9, 812 37 Bratislava, Slovakia

E-mail: *

Abstract: This work aimed to determine the effect of packing density on the sublimation rate in a laboratory freeze dryer. Total amount of sublimed water was determined by gravimetric method while a total of seven experiments were performed under the same conditions (pressure, temperature, and drying time), at different configuration of the vials. The experiments confirmed that the higher the packing density, the lower the drying rate, and vice versa, the lower the packing density, the higher the drying rate. The effect of vials packing density was confirmed by experiments using a plastic rack, while the vials were separated and thus the packing density was lower. In this case, the drying rate was more homogeneous, which contributes to the higher quality of the final product.

Keywords: freeze-drying, gravimetric studies, lyophilization, packing density

Acta Chimica Slovaca, Vol. 13, No. 2, 2020, pp. 30—37, DOI: 10.2478/acs-2020-0021