Dechloromethylation of the berberine to berberrubine — tricks to obtain pure product
Department of Organic Chemistry, Institute of Organic Chemistry, Catalysis and Petrochemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, 812 37 Bratislava, Radlinského 9, Slovakia
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Abstract: Berberine (1), as a compound with interesting biological activities, can be modified at various positions to obtain more potent substances. Modifications at position 9 are based on demethylation with simultaneous dechloration resulting in berberrubine. The most frequent process is thermal dechloromethylation and this work describes this method with detailed tricks to obtain almost pure product in high yield.
Full paper in Portable Document Format: acs_0363.pdf
Acta Chimica Slovaca, Vol. 13, No. 1, 2020, pp. 98—101, DOI: 10.2478/acs-2020-0014