Acta Chimica Slovaca (ACS) publishes papers on fundamental and applied aspects of chemistry, biochemistry, chemical technology, chemical engineering and process control, biotechnology and food technology. Welcome are also topics which include chemical aspects of materials, physical chemistry and chemical physics, analytical chemistry, macromolecular chemistry and biomedical engineering.

Synthetic approaches to dexmedetomidine

Mária Bobošíková, František Mathia, Daniel Végh, Štefan Marchalín *, Michaela Halinkovičová

Institute of Organic Chemistry, Catalysis and Petrochemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, SK-812 37 Bratislava, Slovak Republic

E-mail: *

Abstract: The review is an attempt at critical evaluation of known synthetic procedures used for laboratory and industrial preparation of a synthetic antihypertensive – Dexmedetomidine as to their complexity, published yield and atom economy.

Keywords: Dexmedetomidine, medetomidine, synthesis, sedatives

Full paper in Portable Document Format: acs_0172.pdf

Acta Chimica Slovaca, Vol. 6, No. 2, 2013, pp. 240—244, DOI: 10.2478/acs-2013-0037