Selective solid-phase extraction of phenylcarbamic acid derivatives from a rat serum by molecularly imprinted polymer
Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Slovak Republic
a Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University in Bratislava, Slovak Republic
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Abstract: Molecularly imprinted polymer (MIP) was synthesized using a non-covalent imprinting approach. Methacrylic acid was used as the functional monomer, acetonitrile was used as the porogen and 1-methyl-2-piperidinoethylester of 4-decyloxyphenylcarbamic acid as the imprint molecule (template). Imprinted polymer was utilized as the sorbents for solid-phase extraction (MISPE) to extract derivatives of alkoxyphenylcarbamic acid from spiked rat serum.
Keywords: HPLC, molecularly imprinted polymer, solid-phase extraction
Full paper in Portable Document Format: acs_0016.pdf
Acta Chimica Slovaca, Vol. 1, No. 1, 2008, pp. 175—179