Acta Chimica Slovaca (ACS) publishes papers on fundamental and applied aspects of chemistry, biochemistry, chemical technology, chemical engineering and process control, biotechnology and food technology. Welcome are also topics which include chemical aspects of materials, physical chemistry and chemical physics, analytical chemistry, macromolecular chemistry and biomedical engineering.

Calcium hydroxide: An efficient and mild base for one-pot synthesis of curcumin and it’s analogues

Pramod S. Kulkarni, Dasharath D. Kondhare, Ravi Varala * a, Pudukulathan K. Zubaidha

School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra – 431 606, India
a Department of Chemistry, Rajiv Gandhi University of Knowledge Technologies, Mudhole, Adilabad, Andhra Pradesh – 504 107, India

E-mail: *

Abstract: Calcium hydroxide was found to be an efficient mild base for the one-pot synthesis of curcumin and its analogues obtained by condensation of one equivalent of acetyl acetone with two equivalents of corresponding aromatic aldehyde. The present protocol offers various advantages such as high yields, inexpensive easily available mild base, easy workup and eco-friendly method.

Keywords: Calcium hydroxide, acetyl acetone, substituted benzaldehydes, DMF, Curcumin

Full paper in Portable Document Format: acs_0158.pdf

Acta Chimica Slovaca, Vol. 6, No. 1, 2013, pp. 150—156, DOI: 10.2478/acs-2013-0023